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Researchers turn back the clock on cancer cells to offer new treatment paradigm
03/27/2024
Rhabdoid tumor cells were reverted from a cancerous state to normal. Discover how deletion of quality control protein DCAF5 may treat an undruggable cancer.
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Immunotherapy targeting cancer fusion protein may hold key to treating rare liver cancer
03/19/2024
Explore how a T-cell receptor targeting an oncogenic fusion holds treatment promise in fibrolamellar carcinoma (FLC), a rare liver cancer with poor prognosis.
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Change in MYCN-driven cell state opens therapeutic window in high-risk neuroblastoma
03/19/2024
See how mesenchymal to adrenergic cell change mechanism in MYCN-linked neuroblastoma linked to high MYCN levels, driven by KDM4 induction.
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Scientists find core regulatory circuit controlling identity of aggressive leukemia
03/19/2024
Anaplastic large cell lymphoma is an aggressive form of cancer. Learn how a core regulatory circuit & STAT3 in ALCL may lead to new therapeutic opportunities.
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Role in mitochondrial metabolism paints more complete picture of MCL-1 function
03/18/2024
See how anti-apoptosis oncoprotein MCL-1 also functions in fatty acid metabolism by binding ACSL1 explaining cardiac toxicity in clinical trials
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Rare inflammatory disease responds best to double inhibition
03/06/2024
Ruxolitinib treats hemophagocytic lymphohistiocytosis (HLH) models better than JAK1 or 2 single inhibitors. Discover its promise in an ongoing clinical trial.
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Novel bispecific design improves CAR T–cell immunotherapy for childhood leukemia
02/12/2024
Learn why bispecific chimeric antigen receptor (CAR) T-cell therapy for acute myeloid leukemia (AML) improved treatment, confirmed by artificial intelligence.
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Sara Federico, MD, named director of the Solid Tumor Division at St. Jude Children’s Research Hospital
02/07/2024
Established clinician researcher will focus on novel treatments and clinical trials for difficult-to-treat childhood cancers.
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Inaugural class of Damon Runyon– St. Jude Pediatric Cancer Research Fellows announced
02/01/2024
This initiative supports early-career scientists studying pediatric cancer, addressing a funding gap between pediatric and adult cancer research.
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St. Jude Children’s Research Hospital adds $13 million project to Research Collaboratives Program
01/18/2024
Created as part of the 2022-2027 Strategic Plan, the St. Jude Research Collaboratives program is part of an overall effort by the institution to fund collaborative research addressing complex scientific problems with transformative potential for the diseases treated at St. Jude.
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