Research Summary
Ovarian carcinoma is one of the most deadly neoplastic diseases among women; however, little is known about the molecular etiology of this disease. Dr. Wang’s research focuses on understanding genetic and epigenetic bases of this devastating disease and applying the knowledge onto develop new cancer diagnostics, prevention, and therapeutics. Dr. Wang has developed approaches to elucidate the genetic alterations at both DNA-sequence and copy-number levels, including high-throughput mutational detection and digital karyotyping, a technology that permits the identification of copy number alterations in cancer on a genome-wide scale with high resolution. Using both strategies, she has performed a comprehensive analysis of gynecologic malignancies and her team has identified several novel oncogenes and tumor suppressor genes in ovarian cancers. Her team is currently focusing on revealing the tumor-promoting functions of NOTCH3 signaling and tumor-suppressor functions of the ARID1A pathway. More recently, her team started to explore global epigenetic alterations and elucidating functional roles played by chromatin modifiers during tumor initiation and progression.
Lab
Lab Website: Gynecologic Pathology Laboratory
Selected Publications
Stoeck A, Jung J, Guan B, Wu R-C, Zhu H, Blackshaw S, Shih Ie, Wang TL. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. Plos Genetics . Oct 30;10(10):e1004751. PMID: 25356737
Yuyu Fun, et al, Wang TL* and Shih IeM. Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell, Jul 13;28(1):82-96.
PMID: 2609684 *Corresponding author
Guan B, Suryo Rahmanto Y, Wu RC, Wang Y, Wang Z, Wang TL, Shih IeM. Roles of deletion of arid1a, a tumor suppressor, in mouse ovarian tumorigenesis. J Natl Cancer Inst. 2014 Jun 4;106(7). PMID: 24899687 * Co-corresponding author
Jones S, Wang TL, Shih IeM, Mao TL, Nakayama K, Roden R, Glas R, Slamon D, LA Jr Diaz,Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science. 2010; 330(6001):228-31. PMID: 20826764
Wang TL, Maierhofer C, Speicher MR, Lengauer C, Vogelstein B, Kinzler KW, Velculescu VE. Digital Karyotyping. Proc Natl Acad Sci USA. 2002; 99:16156-16161
Patents
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