Jeffrey Gotts, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #716
San Francisco CA 94143
Phone415-476-0735
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine - Internal Medicine

    Collapse Overview 
    Collapse Overview
    My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury
    NIH F32HL117549Jan 1, 2014 - Jun 30, 2014
    Role: Principal Investigator
    MECHANISMS OF SVZ EXPANSION FOLLOWING CORTICAL INJURY
    NIH F31MH012798Aug 15, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans. Res Sq. 2024 Feb 21. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA. PMID: 38464245; PMCID: PMC10925444.
      View in: PubMed   Mentions:
    2. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2024 Jan 01; 209(1):37-47. Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF, Mercat A, Moss M, Mularski RA, Pesenti A, Qiu H, Ramakrishnan N, Ranieri VM, Riviello ED, Rubin E, Slutsky AS, Thompson BT, Twagirumugabe T, Ware LB, Wick KD. PMID: 37487152; PMCID: PMC10870872.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    3. Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection. Front Immunol. 2023; 14:1076772. Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA. PMID: 36999019; PMCID: PMC10043316.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells. Am J Physiol Lung Cell Mol Physiol. 2022 08 01; 323(2):L152-L164. Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA. PMID: 35670478; PMCID: PMC9559034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. Am J Respir Crit Care Med. 2022 04 15; 205(8):927-935. Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS. PMID: 35050845; PMCID: PMC9838633.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    6. Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2022 06 01; 322(6):L771-L783. Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA. PMID: 35318859; PMCID: PMC9109788.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    7. Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice. Physiol Rep. 2021 11; 9(21):e15081. Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA. PMID: 34755490; PMCID: PMC8578883.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis. J Vasc Surg Cases Innov Tech. 2021 Dec; 7(4):778-780. Gomez-Sanchez CM, Wu BX, Gotts JE, Chang RW. PMID: 34816071; PMCID: PMC8591455.
      View in: PubMed   Mentions: 3  
    9. Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2021 06 01; 320(6):L1085-L1092. Siegel ER, Croze RH, Fang X, Matthay MA, Gotts JE. PMID: 33822656; PMCID: PMC8285627.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    10. Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate. Am J Respir Cell Mol Biol. 2020 12; 63(6):748-757. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE. PMID: 32822237; PMCID: PMC7790140.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    11. The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L218-L227. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA. PMID: 32519893; PMCID: PMC7473934.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Treatment for severe acute respiratory distress syndrome from COVID-19. Lancet Respir Med. 2020 05; 8(5):433-434. Matthay MA, Aldrich JM, Gotts JE. PMID: 32203709; PMCID: PMC7118607.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCellsPHPublic Health
    13. What are the respiratory effects of e-cigarettes? BMJ. 2019 09 30; 366:l5275. Gotts JE, Jordt SE, McConnell R, Tarran R. PMID: 31570493; PMCID: PMC7850161.
      View in: PubMed   Mentions: 172     Fields:    Translation:Humans
    14. Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L717-L736. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. PMID: 31509438; PMCID: PMC6879898.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    15. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 04; 7(4):e14. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. PMID: 30926051.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. High-power vaping injures the human lung. Am J Physiol Lung Cell Mol Physiol. 2019 May 01; 316(5):L703-L704. Gotts JE. PMID: 30838866; PMCID: PMC6589590.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019 02; 7(2):154-162. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. PMID: 30455077; PMCID: PMC7597675.
      View in: PubMed   Mentions: 304     Fields:    Translation:HumansCTClinical Trials
    18. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 11; 27(Suppl 1):s20-s25. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. PMID: 30158203; PMCID: PMC6252496.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    19. Possible hepatotoxicity of IQOS. Tob Control. 2018 11; 27(Suppl 1):s39-s40. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. PMID: 30131373; PMCID: PMC6238953.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    20. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. PMID: 29543040; PMCID: PMC6087899.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 02 01; 197(3):280-281. Gotts JE, Matthay MA. PMID: 29072926.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 11 01; 313(5):L966-L967. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. PMID: 29109110; PMCID: PMC5792183.
      View in: PubMed   Mentions: 2     Fields:    
    23. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. PMID: 28340238; PMCID: PMC5896544.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsPHPublic Health
    24. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. PMID: 28737769; PMCID: PMC5600325.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    25. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L193-L206. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. PMID: 28522559; PMCID: PMC5582932.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimals
    26. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. PMID: 27716790; PMCID: PMC5055332.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 10; 55(4):613-615. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. PMID: 27689795; PMCID: PMC5070109.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    28. Sepsis: pathophysiology and clinical management. BMJ. 2016 05 23; 353:i1585. Gotts JE, Matthay MA. PMID: 27217054.
      View in: PubMed   Mentions: 364     Fields:    Translation:Humans
    29. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. PMID: 25533958; PMCID: PMC4312207.
      View in: PubMed   Mentions: 346     Fields:    Translation:HumansAnimalsCells
    30. Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):797-809. Gotts JE, Matthay MA. PMID: 25453426; PMCID: PMC4254691.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 01; 307(5):L395-406. Gotts JE, Abbott J, Matthay MA. PMID: 25038188; PMCID: PMC4154253.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    32. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. PMID: 25593740; PMCID: PMC4273700.
      View in: PubMed   Mentions: 32  
    33. Treating ARDS: new hope for a tough problem. Lancet Respir Med. 2014 Feb; 2(2):84-5. Gotts JE, Matthay MA. PMID: 24503258.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    34. Cell therapy for lung disease: a step forward. Chest. 2013 Jun; 143(6):1525-1527. Gotts JE, Matthay MA. PMID: 23732575.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Mesenchymal stem cells and the stem cell niche: a new chapter. Am J Physiol Lung Cell Mol Physiol. 2012 Jun 01; 302(11):L1147-9. Gotts JE, Matthay MA. PMID: 22505672.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. Mesenchymal stem cells and acute lung injury. Crit Care Clin. 2011 Jul; 27(3):719-33. Gotts JE, Matthay MA. PMID: 21742225; PMCID: PMC3134785.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    37. Mechanisms of subventricular zone expansion after focal cortical ischemic injury. J Comp Neurol. 2005 Jul 25; 488(2):201-14. Gotts JE, Chesselet MF. PMID: 15924343.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    38. Vascular changes in the subventricular zone after distal cortical lesions. Exp Neurol. 2005 Jul; 194(1):139-50. Gotts JE, Chesselet MF. PMID: 15899251.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    39. Migration and fate of newly born cells after focal cortical ischemia in adult rats. J Neurosci Res. 2005 Apr 15; 80(2):160-71. Gotts JE, Chesselet MF. PMID: 15751027.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    40. Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther. 2002 Jul; 6(1):73-82. Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR. PMID: 12095306.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane. J Neurotrauma. 2000 Nov; 17(11):1067-77. Gotts JE, Press C, Leasure JL, Schallert T. PMID: 11101209.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    42. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8179-84. Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP. PMID: 9223335; PMCID: PMC21577.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
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